- George Washington "Wash" Black, born into slavery and chosen, aged eleven, to serve "Titch" and help with his scientific research. Wash becomes fascinated with science as well as proving himself to be a highly accomplished artist.
- Big Kit, Wash's mother figure, a woman born in Africa and taken as a slave to the Bahamas plantation, who nurtures the young Washington Black.
- Christopher "Titch" Wilde, born into a life of privilege with land in the Caribbean, he is the second born son of the Wilde Family and follows in his father's footsteps as a celebrated scientist.
- Erasmus Wilde, the man who comes to inherit the plantation Wash lives on after the previous master dies. Erasmus is extraordinarily cruel and violent and his arrival causes a wave of suicides among the slaves.
- Tanna Goff, a mixed race woman, the daughter of a scientist, who falls in love with Wash
- G.M. Goff, a respected scientist who begins to work with Wash on an important new project.
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