- Leopold Bloom's home at 7 Eccles Street[12] – Episode 4, Calypso; Episode 17, Ithaca; and Episode 18, Penelope
- Post office, Westland Row – Episode 5, Lotus Eaters
- Sweny's pharmacy, Lombard Street, Lincoln Place[13] (where Bloom bought soap) – Episode 5, Lotus Eaters
- The Freeman's Journal, Prince's Street,[14] off of O'Connell Street – Episode 7, Aeolus
- And – not far away – Graham Lemon's candy shop, 49 Lower O'Connell Street; it starts Episode 8, Lestrygonians
- Davy Byrne's pub – Episode 8, Lestrygonians
- National Library of Ireland – Episode 9, Scylla and Charybdis
- Ormond Hotel[15] on the banks of the Liffey – Episode 11, Sirens
- Barney Kiernan's pub – Episode 12, Cyclops
- Maternity hospital – Episode 14, Oxen of the Sun
- Bella Cohen's brothel – Episode 15, Circe
- Cabman's shelter, Butt Bridge – Episode 16, Eumaeus
The action of the novel moves from one side of Dublin Bay to the other, opening in Sandycove to the South of the city and closing on Howth Head to the North.
