Tobacco Road is set in rural Georgia during the worst years of the Great Depression. It depicts a family of poor white tenant farmers, the Lesters, as some of the many small Southern cotton farmers made redundant by the industrialization of production and the migration into cities. The main character of the novel is Jeeter Lester, an ignorant and sinful man who is redeemed by his love of the land and his faith in the fertility and promise of the soil.
The precise setting of the novel is unclear. The Jeeters' home is said at one point to be located on "the most desirable soil in the entire west-central part of Georgia", but other passages describe it as being close to the Savannah River and Augusta, which are in eastern Georgia. These references would appear to place their home in Richmond County, of which Augusta is the county seat. The county in which the Jeeters live is also said to be adjacent to Burke County, which Richmond County is. However, the county seat of the Jeeters' county is not Augusta but the fictional town of Fuller. The Jeeters are also said to live near the fictional town of McCoy.
