| Character | 1992 West End cast | 1994 Broadway cast | 1998 Film cast | 2009 West End revival cast | 2022 National UK Tour |
|---|---|---|---|---|---|
| Laura Hoff / Little Voice | Jane Horrocks | Hynden Walch | Jane Horrocks | Diana Vickers | Christina Bianco |
| Mari Hoff | Alison Steadman | Rondi Reed | Brenda Blethyn | Lesley Sharp | Shobna Gulati |
| Ray Say | Pete Postlethwaite | George Innes | Michael Caine | Marc Warren | Ian Kelsey |
| Sadie | Annette Badland | Karen Vaccaro | Annette Badland | Rachel Lumberg | Fiona Mulvaney |
| Billy | Adrian Hood | Ian Barford | Ewan McGregor | James Cartwright | Akshay Gulati |
| Mr Boo | George Raistrick | John Christopher Jones | Jim Broadbent | Tony Haygarth | William Ilkley |
| The Phone Man | George Raistrick | John Christopher Jones | Philip Jackson | Tony Haygarth | James Robert Moore |
| U/S Little Voice | Anna Hale |
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