In 2010, it was announced that a television film project based on the book was in development. Oprah Winfrey and Alan Ball were teaming together to bring the biopic to HBO. HBO began production on the film in the summer of 2016. Winfrey executive-produced and starred as Deborah, the daughter of Henrietta Lacks. George C. Wolfe wrote the screenplay and directed the film. Lacks' sons and granddaughter were planned to serve as consultants. The film aired in 2017.
In Alex Garland's film Annihilation (2018), Natalie Portman's character is seen reading the book in one scene; her character is a geneticist and the film explores genetic mutations.