The House with a Clock in Its Walls received a New York Times outstanding book citation and a Michigan Young Readers award nomination.[3] Anita Silvey wrote in Children's Books and Their Creators that Bellairs "established himself as one of the most compelling mystery writers for children" with The House with a Clock in Its Walls.[4]
Kirkus Reviews wrote that Gorey's drawings of the house were "creepy-cozy", and that "Bellairs doesn't bother to supply either motivation or blueprints for the [...] scheme, but if the cavalier and capricious handling of the occult by characters and author alike precludes any bone-deep shudders, the house lives up to its promise of a few gratifying Halloween shivers".[5] The New York Times wrote: "It's the aura of this story—its blend of the everyday and the supernatural—that makes it glow among a plethora of lacklustre occult books this spring" of 1973. It continued: "What the author has done that's so special is to touch both the intellect and the feelings. He has dusted off the paraphernalia of ancient magic and made us newly aware of the difference between good and evil. His dialogue goes snap, crackle and pop. He sets chilling scenes with suspense that tightens like a screw".[6]