The Hot Zone: A Terrifying True Story is a best-selling 1995 nonfiction thriller by Richard Preston about the origins and incidents involving viral hemorrhagic fevers, particularly ebolaviruses and marburgviruses. The basis of the book was Preston's 1992 New Yorker article "Crisis in the Hot Zone".
The filoviruses, Ebola virus, Sudan virus, Marburg virus, and Ravn virus are Biosafety Level 4 agents. Biosafety Level 4 agents are extremely dangerous to humans because they are very infectious, have a high case-fatality rate, and have no known prophylactics, treatments, or cures.
Along with describing the history of the diseases caused by these two Central African diseases, Ebola virus disease and Marburg virus disease, Preston described a 1989 incident in which a relative of Ebola virus, named Reston virus, was discovered at a primate quarantine facility in Reston, Virginia, less than 15 miles (24 km) away from Washington, D.C. The virus found at the facility was a mutated form of the original Ebola virus and was initially mistaken for Simian hemorrhagic fever. The original Reston facility involved in the incident, located at 1946 Isaac Newton Square, was subsequently demolished on 30 May 1995, and a new building was constructed in its place.