- Amandla Stenberg as Starr Carter
- Regina Hall as Lisa Carter, Starr & Sekani's mother and Maverick's wife
- Russell Hornsby as Maverick Carter, Starr, Sekani & Seven's father
- Algee Smith as Khalil Harris, Starr's childhood best friend
- Lamar Johnson as Seven Carter, Starr, Sekani, Kenya and Lyric's older half-brother
- Issa Rae as April Ofrah
- KJ Apa as Chris Bryant, Starr's boyfriend
- Common as Carlos, Lisa's brother and uncle to Starr & Sekani
- Anthony Mackie as King, Iesha's husband, father to Kenya and Lyric, stepfather to Seven
- Dominique Fishback as Kenya, Starr's best friend and one of three half-sisters to Seven
- Sabrina Carpenter as Hailey Grant, one of Starr's school friends
- Megan Lawless as Maya Yang, one of Starr's school friends[7]
- TJ Wright as Sekani Carter, Starr's younger brother and Seven's half-brother
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