There have been several film adaptations of The Brothers Karamazov. They include:
- The Brothers Karamazov (1915 silent film, lost, directed by Victor Tourjansky)
- Die Brüder Karamasoff (1921, directed by Carl Froelich)
- Der Mörder Dimitri Karamasoff (1931, directed by Erich Engels & Fyodor Otsep, starring Fritz Kortner, Anna Sten)
- I fratelli Karamazoff (1947, directed by Giacomo Gentilomo)
- The Brothers Karamazov (1958, directed by Richard Brooks, starring Yul Brynner and William Shatner)
- The Brothers Karamazov (1969, directed by Kirill Lavrov, Ivan Pyryev and Mikhail Ulyanov)
- The Brothers Karamazov (1969, directed by Marcel Bluwal)
A Russian 12-episode mini-series was produced in 2009, and is considered to be as close to the book as possible.
The 2013 Japanese TV drama Karamazov no Kyōdai is an adaptation of the book set in modern-day Japan   that was created by executive producer Sato Misato, screenwriters Ouka Shizuka and Takei Aya, and directors Tsuzuki Junichi, Murakami Shosuke, and Satō Genta.
The Grand Inquisitor was adapted for British television as a one-hour drama titled Inquisition. Starring Derek Jacobi as the inquisitor, it was first broadcast on Channel 5 on 22 December 2002.