Organic Chemistry 9th Edition

Published by Brooks Cole
ISBN 10: 1305080483
ISBN 13: 978-1-30508-048-5

Chapter 20 - Carboxylic Acids and Nitriles - Exercises - Page 648h: 50


See the explanation below.

Work Step by Step

a) Grignard carboxylation is not used because of the acidity of the hydroxyl group. b) Both methods are used. c) Neither methods can be used in this scenario. d) Since the hydroxyl proton interferes with the formation of grignard reaction, use the nitrite only to form the carboxylic acid.
Update this answer!

You can help us out by revising, improving and updating this answer.

Update this answer

After you claim an answer you’ll have 24 hours to send in a draft. An editor will review the submission and either publish your submission or provide feedback.