Organic Chemistry 9th Edition

Published by Brooks Cole
ISBN 10: 1305080483
ISBN 13: 978-1-30508-048-5

Chapter 20 - Carboxylic Acids and Nitriles - Exercises: 50

Answer

See the explanation below.

Work Step by Step

a) Grignard carboxylation is not used because of the acidity of the hydroxyl group. b) Both methods are used. c) Neither methods can be used in this scenario. d) Since the hydroxyl proton interferes with the formation of grignard reaction, use the nitrite only to form the carboxylic acid.
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