Work Step by Step
The following are true about competitive and noncompetitive inhibitors: 1. Competitive inhibitors work by competing with a substrate for binding to an enzyme’s active site; 2. Noncompetitive inhibitors can bind at sites other than the active site of an enzyme, distorting the tertiary protein structure, which alters the shape of the active site, rendering it ineffective for substrate binding; 3. Some noncompetitive inhibitors bind reversibly while some bind irreversibly to their enzyme. 4. Noncompetitive inhibitors attach to the enzyme at an allosteric site.