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Intermediate filaments are generally more stable and less prone to rapid assembly and disassembly, which may limit the ability of motor proteins to move along their surface.
Intermediate filaments are often arranged in a more random, mesh-like network within cells compared to the highly organized, linear arrangements of microtubules and actin filaments. This may make it more difficult for motor proteins to move along intermediate filaments, as there may not be a clear direction or orientation for the motor proteins to follow.
The explanation for the lack of motor proteins that move on intermediate filaments is that intermediate filaments themselves are not dynamic structures like microtubules and actin filaments.
