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Protists and humans have evolved in quite different ways, especially in terms of their chemical and genetic makeup. Human cellular and genetic processes differ significantly from the molecular processes used by parasitic protists. For instance, due to a delayed immune response, when parasitic protists infect humans, the latter have a tendency to have less immunosuppression. The slow identification of protists' antigenic variations is due to the great degree of immunological unfamiliarity that humans have with protist infections.
Additionally, different protists exhibit variations in their physiology, parasitic behaviour, and survival methods, giving rise to the term "junk kingdom." Contrary to bacteria, which are more likely to invade in a predictable fashion, humans' immune systems would have to contend with a variety of parasitic mechanisms of different kinds of protists
