Biology (11th Edition)

Published by McGraw-Hill Education
ISBN 10: 1-25918-813-2
ISBN 13: 978-1-25918-813-8

Chapter 9 - Cell Communication - Review Questions - Synthesize: 2c


Netrin-1 limits the number of cells, since those which grow too far from the crypts will lose the signal (Netrin-1) which prevents cell death. Without the receptor, there is unregulated cell growth/division, which is the major part of tumor formation.

Work Step by Step

Consider first what makes a tumor: uncontrolled cell growth. Then, ask yourself what about this example has to do with the control of cell growth/division: Netrin-1 abundance perceived via its receptor. Thus, no receptor means no control, which sets the stage for tumor formation.
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