The two essential proteins in Tisseel are fibrinogen and thrombin. Thrombin acts on fibrinogen to produce the protein fibrin. Fibrin forms a protein mesh that holds the components of a clot in place.
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When a blood vessel is breached , bleeding naturally occurs. If the breach is just a small tear in a capillary a platelet may be enough to seal the open. In the case of larger tears or wounds the entire coagulation process may be necessary to produce a larger clot. The purpose of the clotting process is to seal the wound and to stop the loss of blood It is also necessary to hold the clot in place until the healing has taken place in the tissues of the blood vessel wall. The structure that holds the clot in place is a mesh formed by strands of the protein fibrin. The endpoint of the normal clotting cascade is to have the enzyme thrombin interact with the protein fibrinogen to produce strands of fibrin which form the fibrin network or mesh Tisseel a commercial preparation that combines preparations of fibrinogen and of thrombin. These product are combined an applied to a wound during certain types of surgery to hasten and ensure proper wound healing Other componentents are sometimes included in the Tisseel package . Some of these are: 1 Aprotinin -- an antifibrinolytic This prolongs the life of a clot in a fibrinolytic environment 2. Clotting factor X111 3. CaCl2