#### Answer

The patient should be given 3 tablets each day.

#### Work Step by Step

$1~lb \approx 0.45~kg$
We can convert 220 pounds to units of kilograms.
$220~lb = \frac{220~lb}{1}\times \frac{0.45~kg}{1~lb} = 99~kg$
We can find the total number of milligrams of the drug which should be administered daily.
$12~mg/kg\times 99~kg = 1188~mg$
We can find the number of tablets which should be given to the patient each day.
$\frac{1188~mg}{400~mg/tablet} = 2.97~tablets$
The patient should be given 3 tablets each day.