#### Answer

The expression is simplified to $-42$.

#### Work Step by Step

Simplifying this expression requires knowing the order of operations.
We multiply and divide from left to right:
$$-10 + (16\div 2)(-4)$$
Simplify:
$$-10 + 8(-4)$$
We multiply again:
$$-10 + (-32)$$
We then do addition and subtraction from left to right. In this case, we are adding a negative number, which means that we subtract the number:
$$-10 - 32$$
The expression is simplified to $-42$.