#### Answer

45

#### Work Step by Step

If you follow the order of operations, to simplify you must solve the exponents first, then divide and multiply, and finally subtract from left to right.
8$^2$-16$\div$2$^2$$\times$4-3
(64)-16$\div$(4)$\times$4-3
64-(4)$\times$4-3
64-(16)-3
(48)-3
45