Answer
neither
Work Step by Step
Given the vectors ${u}=(-2,5,1,0), \quad {v}=\left(\frac{1}{4},-\frac{5}{4}, 0,1\right)$, then
$$ u \cdot v=(-2,5,1,0) \cdot \left(\frac{1}{4},-\frac{5}{4}, 0,1\right)=-\frac{27}{4},$$
So the vectors are not orthogonal, not parallel, they are (neither).