Answer
$(4x-1)(4x+1)$
Work Step by Step
Note that:
$16x^2=(4x)(4x)=(4x)^2$
$1=1^2$
Thus, the given expression is equivalent to:
$(4x)^2-1^2$
Recall:
$a^2-b^2=(a-b)(a+b)$
Factor the expression using the formula above with $a=4x$ and $b=1$ to obtain:
\begin{align*}
(4x)^2-1^2&=(4x-1)(4x+1)
\end{align*}