- William Holden as Joe Gillis (Joseph C. Gillis)
- Gloria Swanson as Norma Desmond
- Erich von Stroheim as Max von Mayerling
- Nancy Olson as Betty Schaefer
- Fred Clark as Sheldrake, film producer
- Lloyd Gough as Morino, Joe's agent
- Jack Webb as Artie Green
- Franklyn Farnum as undertaker
- Larry J. Blake as finance man #1
- Charles Dayton as finance man #2
- Jack Warden as New Year's Eve party guest
- Cecil B. DeMille as himself
- Hedda Hopper as herself
- Sidney Skolsky as himself
- Buster Keaton as himself (bridge player)
- Anna Q. Nilsson as herself (bridge player)
- H. B. Warner as himself (bridge player)
- Ray Evans (pianist at Artie's party)
- Jay Livingston (pianist at Artie's party)
- Robert O'Connor as Jonesy (older guard at Paramount gate)
- Henry Wilcoxon as actor on DeMille's Samson and Delilah set (uncredited)
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