- Mekhi Phifer as Odin James (based on Othello)
- Josh Hartnett as Hugo Goulding (based on Iago)
- Julia Stiles as Desi Brable (based on Desdemona)
- Elden Henson as Roger Calhoun (based on Roderigo)
- Andrew Keegan as Michael Cassio (based on Michael Cassio)
- Rain Phoenix as Emily (based on Emilia)
- Martin Sheen as Coach Duke Goulding (based on the Duke of Venice)
- John Heard as Bob Brable (based on Brabantio)
- Anthony Johnson as Dell
- Rachel Shumate as Brandy (based on Bianca)
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