- Medea: daughter of King Aeëtes (King of Colchis), wife of Jason
- Chorus: Corinthians, hostile to Medea and not Jason
- Nutrix (nurse): nurse of Medea
- Creon: King of Corinth, father of Princess Creusa
- Jason: son of Aeson and husband of Medea who leaves her for the princess
- Nuntius (messenger)
- Two sons of Medea and Jason: mute characters
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