- Esperanza Ortega: The protagonist, the 13-year-old daughter of wealthy Mexican landowners, who spends most of the novel living in poverty in California
- Ramona Ortega: Esperanza's mother
- Sixto Ortega: Esperanza's father
- Abuelita: Esperanza's grandmother
- Tio Luis: Esperanza's uncle who tries to marry Ramona after Sixto's death and burnt down the house after Ramona rejects
- Miguel: Hortensia's son and Esperanza's friend and agemate
- Pepe and Lupe: Alfonso's family members who Esperanza meets after moving to California
- Isabel: Miguel’s cousin
- Carmen: The chicken and egg lady
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