Tracey Ullman played Maddow in her Showtime comedy series Tracey Ullman's State of the Union. Maddow invited Ullman on her show and interviewed her in January 2010.[134]
Abby Elliott and Melissa Villasenor have both played Maddow in sketches on Saturday Night Live.[135]
Maddow appeared as a character on the November 3, 2013 episode of The Simpsons, "Four Regrettings and a Funeral".[136][137][138][139]
Maddow appeared at the start of "Trump: The Rusical" on RuPaul's Drag Race season 11 as the star of a mini-challenge where the contestants had to dress up as Maddow and read from a teleprompter.[140]
Maddow is the voice of Vesper Fairchild in the television series Batwoman.[141] In March of 2010 she wrote the introduction to the Batwoman: Elegy trade paperback, in which she noted her appreciation for the work of writer Greg Rucka.[142] She appeared as herself on the Netflix series House of Cards.[143][144]
Maddow also makes a cameo as herself in the 2023 romance film Red, White & Royal Blue.
