- Ryan Gosling as K
- Harrison Ford as Rick Deckard
- Ana de Armas as Joi
- Sylvia Hoeks as Luv
- Robin Wright as Lt. Joshi
- Mackenzie Davis as Mariette
- Carla Juri as Dr. Ana Stelline
- Lennie James as Mister Cotton
- Dave Bautista as Sapper Morton
- Jared Leto as Niander Wallace
- Edward James Olmos as Gaff
- Barkhad Abdi as Doc Badger
- Hiam Abbass as Freysa
- David Dastmalchian as Coco
- Wood Harris as Nandez
- Sallie Harmsen as Replicant
- Tómas Lemarquis as Wallace Corporation file clerk
Archival footage, audio, and stills of Sean Young from the original film are used to represent both her original character of Rachael and a duplicate of the character created by Niander Wallace.[13] Young's likeness was digitally superimposed onto Loren Peta, who was coached by Young on how to recreate her performance from the first film. The voice of the replicant was created with the use of a sound-alike actress to Young.[14] Young was credited for her work.
