As I Lay Dying is consistently ranked among the best novels of 20th-century literature. The novel has been reprinted by the Modern Library, the Library of America, and numerous publishers, including Chatto and Windus in 1970, Random House in 1990, Tandem Library in 1991, and Vintage Books in 1996. and the Folio Society in 2013. Faulkner was awarded the Nobel Prize in Literature in 1949 for his novels prior to that date, with this book being among them. 
The novel has also directly influenced a number of other critically acclaimed books, including British author Graham Swift's 1996 Booker Prize-winning novel Last Orders and Suzan-Lori Parks's Getting Mother's Body, and Jesmyn Ward’s Sing, Unburied, Sing.
In 1998, the Modern Library ranked As I Lay Dying 35th on its list of the 100 best English-language novels of the 20th century.
The Grammy-nominated metalcore band As I Lay Dying derived its name from this novel.
The character Darl Bundren also appeared in Faulkner's 1935 short story "Uncle Willy".