The main body of the poem describes the feast given by Alexander the Great at the Persian capital Persepolis, after his defeat of Darius in 331 BC.[1] Alexander's bard Timotheus sings praises of him. Alexander's emotions are manipulated by the singer's poetry and music. Timotheus glorifies him as a god, puffing up Alexander's pride. He then sings of the pleasures of wine, encouraging Alexander to drink. Seeing Alexander becoming too boisterous, he sings of the sad death of Darius; the king becomes quiet. He then lauds the beauty of Thaïs, Alexander's lover, making the king's heart melt. Finally, he encourages feelings of anger and vengeance, causing Thaïs and Alexander to burn down the Persian palace in revenge for Persia's previous outrages against Greece.
The poem then moves ahead in time to describe Saint Cecilia, "inventress of the vocal frame", who is traditionally supposed to have created the first organ and to have instituted Christian sacred music. The poem concludes that while Timotheus "Raised a mortal to the skies, / She drew an angel down".
