Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 27 - Protein Metabolism - Problems - Page 1151: 11

Answer

Isoleucine is structurally similar to Valine. Within the aminoacylation process, distinguishing between the two residues requires a secondary filter of a proofreading mechanism. Histidine has a more distinct structure, so it is therefore more fit for binding specificity.

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