Lehninger Principles of Biochemistry 6th Edition

Published by W.H. Freeman
ISBN 10: 1-42923-414-8
ISBN 13: 978-1-42923-414-6

Chapter 27 - Protein Metabolism - Problems - Page 1151: 13

Answer

The protein product will be led into the ER, where different signals will modulate targeting. SRP will bind with the amino terminal to guide the newly synthesized polypeptide to designated ER receptors. The NLS is never accessible to the proteins that are responsible for protein targeting.

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