Answer
$x^2y^2(x^3y^3+x^2y+xy-1)$
Work Step by Step
Factoring the negative $GCF=
x^2y^2
$, the factored form of the given expression, $
x^5y^5+x^4y^3+x^3y^3-x^2y^2
,$ is
\begin{align*}
x^2y^2(x^3y^3+x^2y+xy-1)
.\end{align*}
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