Wise Blood is the first novel by American author Flannery O'Connor, published in 1952. The novel was assembled from disparate stories first published in Mademoiselle, Sewanee Review and Partisan Review. The first chapter is an expanded version of her Master's thesis, "The Train", and other chapters are reworked versions of "The Peeler," "The Heart of the Park" and "Enoch and the Gorilla". The novel concerns a returning World War II veteran who, haunted by a lifelong crisis of faith, resolves to form an anti-religious ministry in an eccentric, fictionalized Southern city after finding his family homestead abandoned without a trace.
The novel received little critical attention when it first appeared but has since come to be appreciated as a classic work of "low comedy and high seriousness" with disturbing religious themes. It was placed 62nd in The Guardian's list of 100 greatest novels.