The Cell: A Molecular Approach 7th Edition

Published by Sinauer Associates
ISBN 10: 160535290X
ISBN 13: 978-1-60535-290-9

Chapter 2 - Molecules and Membranes - Question - Page 78: 10


Amino acids in the membrane spanning regions must be hydrophobic. Positively charged amino acids cannot form stable associations with membrane lipids, and, therefore, are very uncommon. Lys, Gln, Asp, and Arg are positively charged amino acids. Ala has a hydrophobic side chain.

Work Step by Step

They must be hydrophobic in order to interact with the hydrophobic environment of the membrane. Since, Lys, Gln, Asp, and Arg are positively charged, they are generally not found in membrane spanning regions. Since Ala has a hydrophobic side chain, it can be a part of the membrane spanning region.
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