Act 2, 3, 4, And 5
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I think he should be pitied to an extent. He was a Moor in a white world. He had to constantly prove his worth and masculinity. Consequently, he saw things in absolutes and Iago was quick to exploit his weakness. We can see Othello's psyche like a slow train wreck once Iago ignites his paranoia.
Anyone who has to deal with Iago should definitely be pitied. He's basically the devil: controlling, manipulative, and focused on revenge and his personal misgivings. None of them really stood a chance.