How does the quote relate thematically to the book Othello?

Alas, thrice-gentle Cassio, My advocation is not now in tune. My lord is not my lord, nor should I know him Were he in favor as in humor altered. So help me every spirit sanctified As I have spoken for you all my best And stood within the blank of his displeasure For my free speech. You must awhile be patient. What I can do I will, and more I will Than for myself I dare. Let that suffice you.

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Othello is a slave to his passions. He sees things in absolutes and Iago knows this and exploits it. In matters of military, Othello can be subtle and wise. In matters of the heart Othello is rash and judgmental. It couldn't have been easy being a "moor" in Shakespeare's world at that time. Othello is defensive when it comes to how he is scene in society, especially when it comes to matters of sex marriage, and emotional stability. Othello's judgment in these matters is easily clouded with the slightest doubt. This doubt/ lack of control snowballs quickly into paranoia and violence. Here Othello is no longer tempered by Desdemona’s gentle rationality. Othello is bent on destruction of everything he loves.