what are the physical and psycological alenation in Macbeth?

There are two types of alienations in Macbeth's play

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Macbeth finds himself increasingly isolated because of his thirst for power. With his thirst for power comes a definite sense of paranoia. He believes that his throne is always under attack. He kills more and more people, like Macduff's whole family for his perceived safety. By the end of the play he is physically alone. All his subjects have fled the castle.