I think you are essentially asking a thematic question here. Go to the themes section at GradeSaver and you can formulate quite a few important questions that Angelou poses. For me, I would pick the following:
Race and appearance
In the world Maya grows up in, beauty is narrowly defined as being white, with blond hair and blue eyes. Maya believes as a child that being black means being ugly, and thinks of her appearance as a "black ugly dream" that she will wake out of. Is this true of society today?