Dr. Jekyll and Mr. Hyde

What information do we learn from Poole about Jeckyll’s behaviour in Chapter 8?

What kind of things do we learn about Dr. Jekyll's behavious in chapter 8 (the last night)? How does poole describe him? 

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Poole appears quite distraught, and Utterson offers him a glass of wine to calm his nerves. Poole accepts, although he leaves the wine untouched. Poole reveals that he has come to Utterson in desperation. He is severely concerned about Dr. Jekyll's well being, as the man has been locked in his cabinet for weeks and allows no one to see him.