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One January day in Regent's Park, Jekyll turns into Hyde naturally..... without drugs. He is losing control, and Hyde is taking control.
And at the very moment of that vain-glorious thought, a qualm came over me, a horrid nausea and the most deadly shuddering. These passed away, and left me faint; and then as in its turn the faintness subsided, I began to be aware of a change in the temper of my thoughts, a greater boldness, a contempt of danger, a solution of the bonds of obligation. I looked down; my clothes hung formlessly on my shrunken limbs; the hand that lay on my knee was corded and hairy. I was once more Edward Hyde. A moment before I had been safe of all men’s respect, wealthy, beloved — the cloth laying for me in the dining-room at home; and now I was the common quarry of mankind, hunted, houseless, a known murderer, thrall to the gallows.
Dr. Jekyll and Mr. Hyde