Answer
$R=0$
$x+4$ is a factor.
Work Step by Step
$f\left( x\right) =x^{6}-16x^{4}+x^{2}-16=\left( x+4\right) q\left( x\right) +R$
$\Rightarrow f\left( -4\right) =0=R$
Since $R=0$, $x+4$ is a factor.
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