The birthmark

Aylmer views the red hand-shaped birthmark on Georgiana’s cheek as a grotesque imperfection belonging to an otherwise perfect human. Rather than accept the physical flaw and protect her safety, Aylmer performs a risky procedure to rid her skin of the mark, which results in her death. In other words, Aylmer triumphs the sheer drive for control and scientific success over his relationship with his own wife. Because of his overly pragmatic mind that operates outside of decency and morality, Aylmer's character shows us the dangers of unchecked ambition and intellect, as well as the limitations of scientific pursuits.