How does Aylmer’s obsession with Georgiana's birthmark affect their relationship?

Aylmer's obsession with Georgiana's birthmark makes her feel ugly. His desire to remove the birthmark creates a great chasm, and his wife, is frightened by the things he tells her..... his dreams. As a result, she practically begs him to rid her of something that never before bothered her, and in the end, his elixir ends her life.