Of Mice and Men

is it lennie, because his handicap inherently isolates him from the other ranchers

who is the loneliest character in mice and men

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Last updated by Aslan
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At least Lennie has George to care about him. I think the loneliest characters are Crooks and Curley's wife. Crooks is isolated because of his color while Curley's wife, perhaps the most pathetic character, wanders the ranch hoping that somebody might talk to her.