The professional name of singer-songwriter Natalie Laura Mering, Weyes Blood, was inspired by the novel.[7]
Melbourne musician Keith Glass used the pseudonym Onie J. Holy, a con artist/preacher in Wise Blood. An album God, Guns and Guts was released in 1987.
Heavy metal band Corrosion of Conformity released an album entitled "Wiseblood" in 1996.
PJ Harvey cited the novel as a huge inspiration for her writing on her 1995 album To Bring You My Love.[8]
Red Label Catharsis named its second album and title track, "Jesus Made it Beautiful To Haunt Her" directly from one specific page in Wiseblood where Sabbath Lily tells Hazel a story about a mother who strangles her baby [9]