A film was made of Wise Blood in 1979, directed by John Huston, and starring Brad Dourif as Hazel Motes and John Huston himself as the evangelist grandfather. Shot mostly in Macon, Georgia, it is a fairly literal filming of the novel.
An immersive opera and gallery installation, WISE BLOOD , libretto adapted from the novel by Anthony Gatto, was commissioned by Walker Art Center and The Soap Factory (Minneapolis, Minnesota USA) in May and June 2015. From the Soap Factory website: "Visual artist Chris Larson and composer Anthony Gatto join forces to bring the darkly humorous world of Flannery O'Connor's WISE BLOOD to life. Set in the post-industrial beauty of a 130-year-old factory space turned art gallery, this immersive opera takes the audience on a journey alongside the eccentric and always captivating characters of this story. The audience is brought directly into, around and through large scale installation pieces, kinetic sculptures and projections. WISE BLOOD features an incredibly diverse cast of performers. The musicians of the Adam Meckler orchestra, Youngblood Brass Band, provide the musical core to this Southern Gothic Tale."