Volpone was adapted by Jules Romains and Stefan Zweig in their 1928 production, with the ending changed so that Mosca ends up with Volpone's money. This version was used by George Antheil in his 1953 opera Volpone.
In 1941 a French film version was released, under the direction of noted filmmaker Maurice Tourneur. Begun in 1938 by Jacques de Baroncelli, the production shut down because of financial difficulties. Tourneur took over and the shooting resumed in 1940. This version also used portions of the adaptation by Romains and Zweig.
A short-lived 1964 Broadway musical adaptation entitled Foxy moved the play's setting to the Yukon during the gold rush of 1898.
The stage adaptation Sly Fox, by Larry Gelbart, updated the setting from Renaissance Venice to 19th century San Francisco, and changed the tone from satire to farce.
The Honey Pot is a 1967 film by Joseph L. Mankiewicz based on Volpone, although with a romantic subplot and sentimental trappings. It featured Rex Harrison in the main role, Cliff Robertson as Mosca ("McFly"), and Maggie Smith as the love interest. A portion of the original play is presented in private performance for Harrison's character, who states that it is his favourite.
In France, there have been three further video and DVD adaptations of Volpone based on versions of the Stefan Zweig/Jules Romains script: in 1978, Jean Meyer directed a production in the 'théâtre de boulevard' style for the Théâtre de Marigny and Panorama (Au Théâtre ce soir), starring himself as Corbaccio, Jean Le Poulain as Volpone, Francis Huster as Mosca and Claude Jade as Colomba (Celia). This was followed in 2001 by a production directed by Francis Perrin with a script that resembles the Zweig/Romains text but rewritten in pseudo-Elizabethan style by Jean Collette and Toni Cecchinato. Bernard Haller plays the part of Volpone, Francis Perrin plays Mosca, and Thibaut Lorain plays Lady Would-Be. In 2003, the play was rewritten for television by Eric-Emmanuel Schmitt for a production starring Gérard Depardieu as Volpone and Daniel Prévost as Mosca. The ending is changed to see Volpone and Mosca escaping together with Corbaccio's wife.
In 1988 the film was adapted for Italian cinema by Maurizio Ponzi, with the title Il Volpone. Set in modern Liguria, it features Paolo Villaggio as Ugo Maria Volpone and Enrico Montesano as Mosca.
In 2004 the Wolf Trap Opera Company, Viennna, Virginia, commissioned and produced a new opera based on the play. The score was written by John Musto with libretto by Mark Campbell. The world premiere took place at The Barns at Wolf Trap on 10 March 2004. The opera was produced again in 2007 by the Wolf Trap Opera Company with a new cast featuring Joshua Jeremiah, Jeremy Little, Faith Sherman, and Lisa Hopkins. This production was recorded live at The Barns at Wolf Trap for Wolf Trap Recordings and was nominated in 2010 for a Grammy Award for Best Opera Recording.