Ulysses in Nighttown, based on Episode 15 ("Circe"), premiered off-Broadway in 1958, with Zero Mostel as Bloom; it debuted on Broadway in 1974.
In 2006, playwright Sheila Callaghan's Dead City, a contemporary stage adaptation of the book set in New York City, and featuring the male figures Bloom and Dedalus re-imagined as female characters Samantha Blossom and Jewel Jupiter, was produced in Manhattan by New Georges.
In 2013, a new stage adaptation of the novel, Gibraltar, was produced in New York by the Irish Repertory Theatre. It was written by and starred Patrick Fitzgerald and directed by Terry Kinney. This two-person play focused on the love story of Bloom and Molly, played by Cara Seymour.
In 1967, a film version of the book was directed by Joseph Strick. Starring Milo O'Shea as Bloom, it was nominated for an Academy Award for Best Adapted Screenplay.
In 2003, a movie version Bloom was released starring Stephen Rea and Angeline Ball.
In 1988, a documentary, the episode "James Joyce's Ulysses" in a series titled The Modern World: Ten Great Writers, was shown on Channel 4, where some of the most famous scenes from the novel were dramatised. David Suchet played Leopold Bloom.
On Bloomsday 1982, RTÉ, Ireland's national broadcaster, aired a full-cast, unabridged, dramatised radio production of Ulysses, that ran uninterrupted for 29 hours and 45 minutes. It has been commercially released as a boxed set of 32 CDs, and as an MP3 set on three CDs.
BBC Radio broadcast a highly abridged dramatisation of Ulysses read by Sinéad Cusack, James Greene, Stephen Rea, Norman Rodway, and others in 1993. This performance had a running time of 5 hours and 50 minutes.
The unabridged text of Ulysses has been performed by Jim Norton, with Marcella Riordan. This recording was released by Naxos Records on 22 audio CDs in 2004. It follows an earlier abridged recording with the same actors.
On Bloomsday 2010, author Frank Delaney launched a series of short weekly podcasts called Re:Joyce that take listeners through Ulysses page-by-page discussing its allusions, historical context and references.
BBC Radio 4 aired a new nine-part adaptation dramatised by Robin Brooks and produced/directed by Jeremy Mortimer, and starring Stephen Rea as the Narrator, Henry Goodman as Leopold Bloom, Niamh Cusack as Molly Bloom and Andrew Scott as Stephen Dedalus, for Bloomsday 2012, beginning on 16 June 2012.
The song "Flower of the Mountain" by Kate Bush (originally the eponymous track off The Sensual World) sets to music the end of Molly Bloom's soliloquy.
The Joyce novel is mentioned in the lyrics of the title track of Ulysses, a 2014 album by Canadian indie rock band Current Swell. The album cover art is also an homage to the first edition cover of the book.
Jacob Appel's novel, The Biology of Luck (2013), is a retelling of Ulysses set in New York City. The novel features an inept tour guide, Larry Bloom, whose adventures parallel those of Leopold Bloom through Dublin.