- Ren, a trapeze dancer who works at the sex club Scales and Tails, who survives the plague by being isolated in the club's biohazard containment chamber. She previously dated Jimmy (Snowman) in school.
- Toby, a God's Gardener who goes into hiding to escape a dangerous stalker, by working in a high-end spa.
Oryx, Crake and Jimmy appear in cameo roles over the course of the book with the protagonists Ren and Toby unaware that these characters are eventually responsible for the pandemic. Notably, while the first book shows the world through the eyes of Jimmy and women are reduced to one-dimensional characters; here the women, Ren and Toby, are fully realised characters while Jimmy and Crake are only shown through the women's obfuscated perspective.