Edward Loder used the work as the basis for his 1855 opera Raymond and Agnes.
The French writer Antonin Artaud's only full-length novel bears the same name and is a "loose translation" of Lewis's.
Luis Buñuel and Jean-Claude Carrière attempted to film a version of The Monk in the 1960s, but the project was halted due to lack of funds. Buñuel's friend, the Greek director Ado Kyrou, used this script as the basis for his 1972 film version. Le Moine (English The Monk) boasted an international cast with Franco Nero in the title role. The film also starred Nathalie Delon, Eliana de Santis, Nadja Tiller and Nicol Williamson.
In 1990 The Monk was produced by Celtic Films. It starred Paul McGann as the title character, and was written and directed by Francisco Lara Polop.
Grant Morrison and Klaus Janson's 1990 DC graphic novel Batman: Gothic relies heavily and overtly upon the Monk, combined with elements of Don Giovanni, as the inspiration for the plot.
A film adaption, The Monk, was made by French-German director Dominik Moll in 2011, it was shot in Madrid and stars Vincent Cassel, Déborah François, Geraldine Chaplin, and Sergi López. Shooting began in mid April and was set for 12 weeks.
A stage adaptation by Benji Sperring for Tarquin Productions is running at Baron's Court Theatre, London, from 16 October to 3 November 2012.
A musical comedy based on the novel is being developed. It was workshopped at Carnegie Mellon University three times between March 2010 and March 2012, written and directed by Alex Rice and starring Grey Henson (The Book of Mormon) and Corey Cott (Newsies).