The wide appeal of Saint-Exupéry's novella has led to it being adapted into numerous forms over the decades. Additionally, the little prince character himself has been adapted to a number of promotional roles, including as a symbol of environmental protection, by the Toshiba Group. He has also been portrayed as a "virtual ambassador" in a campaign against smoking, employed by the Veolia Energy Services Group,  and his name was used as an episode title in the TV series Lost.
The multi-layered fable, styled as a children's story with its philosophical elements of irony and paradox directed towards adults, allowed The Little Prince to be transferred into various other art forms and media, including:
- Vinyl record, cassette and CD: as early as 1954 several audio editions in multiple languages were created on vinyl record, cassette tape and much latter as a CD, with one English version narrated by Richard Burton.
- Radio broadcasts: radio plays were produced in the United States, with Raymond Burr, in 1956 and by Bonnie Greer on the United Kingdom's BBC in 2000.
- Film and TV: the story has been created as a movie as early as 1966 in a Soviet-Lithuanian production, with its first English movie version in 1974 produced in the United States featuring Bob Fosse, who choreographed his own dance sequence as The Snake, and Gene Wilder as The Fox. A new 3D film combining computer and stop motion animation will be released in 2015.
- Stage: The Little Prince's popular appeal has lent itself to widespread dramatic adaptations in live stage productions at both the professional and amateur levels. It has become a staple of numerous stage companies, with dozens of productions created.
- Graphic novel: a new printed version of the story in comic book form, by Joann Sfar in 2008, drew widespread notice.
- Pop-Up Book: a new printed edition, using the original text (as translated by Richard Howard in 2000) and St. Exupery's original drawings as the basis for elaborate pop-up illustrations, was published by Houghton Mifflin Harcourt (ISBN 978-0-547-26069-3, 1st ed. 2009).
- Opera and ballet: several operatic and ballet versions of the novella have been produced as early as the Russian Malen′kiy, first performed in 1978 with a symphony score composed in the 1960s.
- Anime: a Japanese animation TV series was made in 1978 Hoshi no Ojisama Petit Prince, containing 39 episodes that do not follow the plot of the original novella. Each episode would contain an adventure for planet Earth where the little prince meets different people each time, and makes friends. Some key elements of the original story have been kept. Namely, the little prince's golden hair, his scarf and laughter. Also, his planet name (B-612), the rose and the three volcanoes. The anime had been aired and dubbed into many languages: Arabic, French, German, Italian, Polish, Portuguese and Spanish.
- Other: a number of musical references, game boards and a video game version of the novella have been released.
In 1997, Jean-Pierre Davidts wrote what could be considered a sequel to The Little Prince, entitled Le petit prince retrouvé (The Little Prince Returns). In this version, the narrator is a shipwrecked man who encounters the little prince on a lone island; the prince has returned to find help against a tiger who threatens his sheep. Another sequel titled The Return of the Little Prince was written by former actress Ysatis de Saint-Simone, niece of Consuelo de Saint Exupery.